Effect of processing variables on micro particulate system of aceclofenac

Microparticulate systems of aceclofenac were prepared by modified solvent evaporation method using different variables such as polymer [cellulose acetate]: drug ratios [1:9, 1:6, 1:3, and 1:1], agitation speeds [500-1500 rpm] and stirring time [5-15 min]. The effects of processing variables were evaluated by microparticle size and entrapment efficiency. The average microparticle size increases from 80.2 +/- 1.45 to 97.3 +/- 2.06